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What is Avmacol®?

Avmacol® is an innovative supplement that supports sulforaphane production by providing glucoraphanin, also known as sulforaphane glucosinolate, and Myrosimax® (Active Myrosinase Enzyme) via our Sulforaphane Production System®.

Sulforaphane promotes your body’s natural detoxification process for certain environmental threats found in the air you breathe, the food you eat, and the water you drink. Research has shown sulforaphane also supports the body’s defenses against inflammation, oxidative stress and cell damage.

What is Sulforaphane?

The Sulforaphane and Broccoli Connection

Sulforaphane is a compound that is typically associated with broccoli and broccoli sprouts, as well as other cruciferous vegetables like Brussels sprouts, arugula and cauliflower. This is because these vegetables provide the necessary ingredients for sulforaphane production: glucoraphanin, also known as sulforaphane glucosinolate, and active myrosinase enzyme.

Sulforaphane is formed when myrosinase transforms glucoraphanin. In plant cells, glucoraphanin and myrosinase are kept separate and only interact when these components are mixed (i.e. chewed), allowing the components to come together and for the transformation to proceed.

Supports Cellular Detoxification

Sulforaphane has been shown to increase Nrf2 which regulates the expression of a variety of Phase II antioxidant and detoxification enzymes

Heat Shock Response

Sulforaphane increases the Heat Shock Response which facilitates and maintains proper folding of proteins during times of cellular stress.

NF-kB

Sulforaphane has been shown to decrease NF-kB, which regulates the expression of certain proteins involved in the inflammatory response.

Avmacol and Sulforaphane

The Avmacol® brand contains both glucoraphanin and Myrosimax® (Active Myrosinase Enzyme), the essential ingredients needed to promote sulforaphane production.

Avmacol® products are supported with human research. Our exclusive Sulforaphane Production System® is validated in humans by measuring metabolites of sulforaphane collected in the urine.

Because of the Sulforaphane Production System® exclusive to Avmacol®, the Avmacol® brand has been selected for use in more sulforaphane human clinical trials than any other supplement.

Why Can't I Just Eat Broccoli?

Since sulforaphane is associated with cruciferous vegetables, namely broccoli and broccoli sprouts, many people think they can get the benefits of sulforaphane just by eating their vegetables. Unfortunately, it isn’t that simple, as sulforaphane itself is not found in broccoli. Rather it is the essential ingredients, glucoraphanin and myrosinase, that are present. Unfortunately, there may not be enough of either compound in the plant to allow for adequate sulforaphane production. This can be due to seed quality, soil composition, the age of the plant, and many other factors.

Additionally, any myrosinase enzyme that is present in the plant can be destroyed during the cooking process. So while glucoraphanin and the myrosinase enzyme can be found in the vegetables you eat, the ones you buy from the market are not necessarily reliable sources of either compound.

Backed by Research

Nutramax Laboratories, the manufacturer of Avmacol, takes pride in providing the very highest standards of research—both in supporting peer-reviewed studies across disciplines and in replicating findings in their own work. Nutramax's rigorous approach is driven by a desire to provide families with supplements they can truly trust. Both in quality of ingredients and research, the company's laboratory practices set the standard for our industry.

The Avmacol®️ brand has been selected for use in more sulforaphane human clinical trials than any other supplement, because Nutramax is committed to driving research forward and they hold their products to the highest standard.

In accordance with our mandate to provide access to the latest peer-reviewed research, the following links have been provided to help our patients better understand Sulforaphane :

Zimmerman, A. W., Singh, K., Connors, S. L., Liu, H., Panjwani, A. A., Lee, L. C., Diggins, E., Foley, A., Melnyk, S., Singh, I. N., James, S. J., Frye, R. E., & Fahey, J. W. (2021). Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder. Molecular autism, 12(1), 38. https://doi.org/10.1186/s13229-021-00447-5

Singh, K., Connors, S. L., Macklin, E. A., Smith, K. D., Fahey, J. W., Talalay, P., & Zimmerman, A. W. (2014). Sulforaphane treatment of autism spectrum disorder (ASD). Proceedings of the National Academy of Sciences of the United States of America, 111(43), 15550–15555. https://doi.org/10.1073/pnas.1416940111

Momtazmanesh, S., Amirimoghaddam-Yazdi, Z., Moghaddam, H. S., Mohammadi, M. R., & Akhondzadeh, S. (2020). Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double-blind, placebo-controlled clinical trial. Psychiatry and clinical neurosciences, 74(7), 398–405. https://doi.org/10.1111/pcn.13016

Bent, S., Lawton, B., Warren, T., Widjaja, F., Dang, K., Fahey, J. W., Cornblatt, B., Kinchen, J. M., Delucchi, K., & Hendren, R. L. (2018). Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli. Molecular autism, 9, 35. https://doi.org/10.1186/s13229-018-0218-4

Way, H., Williams, G., Hausman-Cohen, S., & Reeder, J. (2021). Genomics as a Clinical Decision Support Tool: Successful Proof of Concept for Improved ASD Outcomes. Journal of personalized medicine, 11(7), 596. https://doi.org/10.3390/jpm11070596

Liu, F., Huang, J., Hei, G., Wu, R., & Liu, Z. (2020). Effects of sulforaphane on cognitive function in patients with frontal brain damage: study protocol for a randomised controlled trial. BMJ open, 10(10), e037543. https://doi.org/10.1136/bmjopen-2020-037543
Rong, Y., Huang, L., Yi, K., Chen, H., Liu, S., Zhang, W., Yuan, C., Song, X., & Wang, F. (2020). Co-administration of sulforaphane and doxorubicin attenuates breast cancer growth by preventing the accumulation of myeloid-derived suppressor cells. Cancer letters, 493, 189–196. https://doi.org/10.1016/j.canlet.2020.08.041

Traka, M. H., Melchini, A., Coode-Bate, J., Al Kadhi, O., Saha, S., Defernez, M., Troncoso-Rey, P., Kibblewhite, H., O'Neill, C. M., Bernuzzi, F., Mythen, L., Hughes, J., Needs, P. W., Dainty, J. R., Savva, G. M., Mills, R. D., Ball, R. Y., Cooper, C. S., & Mithen, R. F. (2019). Transcriptional changes in prostate of men on active surveillance after a 12-mo glucoraphanin-rich broccoli intervention-results from the Effect of Sulforaphane on prostate CAncer PrEvention (ESCAPE) randomized controlled trial. The American journal of clinical nutrition, 109(4), 1133–1144. https://doi.org/10.1093/ajcn/nqz012

Calcabrini, C., Maffei, F., Turrini, E., & Fimognari, C. (2020). Sulforaphane Potentiates Anticancer Effects of Doxorubicin and Cisplatin and Mitigates Their Toxic Effects. Frontiers in pharmacology, 11, 567. https://doi.org/10.3389/fphar.2020.00567
Yusin, J., Wang, V., Henning, S. M., Yang, J., Tseng, C. H., Thames, G., Arnold, I., Heber, D., Lee, R. P., Sanavio, L., Pan, Y., Qin, T., & Li, Z. (2021). The Effect of Broccoli Sprout Extract on Seasonal Grass Pollen-Induced Allergic Rhinitis. Nutrients, 13(4), 1337. https://doi.org/10.3390/nu13041337
Chen, J. G., Johnson, J., Egner, P., Ng, D., Zhu, J., Wang, J. B., Xue, X. F., Sun, Y., Zhang, Y. H., Lu, L. L., Chen, Y. S., Wu, Y., Zhu, Y. R., Carmella, S., Hecht, S., Jacobson, L., Muñoz, A., Kensler, K., Rule, A., Fahey, J., … Groopman, J. (2019). Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China. The American journal of clinical nutrition, 110(3), 675–684. https://doi.org/10.1093/ajcn/nqz122


Discussion on Sulforaphane by Brian Cornblatt

What are the Ingredients?

The ingredients in Avmacol®, broccoli seed extract (Glucoraphanin) and Myrosimax® (Active Myrosinase Enzyme), are the essential ingredients necessary for sulforaphane production in the body.

Supplement Facts

Directions for Use: Take two (2) tablets per day (can be adjusted depending on your doctor’s recommendation) with a meal. If you have a condition that requires medical attention always consult your physician before taking any dietary supplement.

Avmacol® tablets may be swallowed or crushed and mixed with foods such as yogurt, applesauce or smoothies for easier consumption.

OTHER INGREDIENTS: MICROCRYSTALLINE CELLULOSE, MALTODEXTRIN, HYDROXYPROPYL CELLULOSE, STARCH

CONTAINS < 2% OF: CROSCARMELLOSE SODIUM, SILICON DIOXIDE, AND MAGNESIUM STEARATE

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